Among men it increased from 1. Between 5 and three in 1000 and in women with 0. 5
another in 1000.
, stated that "no need" for patients
stop taking the drug on the basis of research alone. MHRA collaborated with scientists at Oxford University Cancer Group Epidemiology
look at the data from the UK General Practice Research
database that anonymous patient records about six million people
. Among people aged 40 years and older, 2954 was esophageal cancer, stomach was 2018
cancer and 10,641 had bowel cancer, all diagnosed between 1995 and 2005. Results also showed that the probability of esophageal cancer by 30 percent
higher in people with one or more previous requirements for receiving bisphosphonates >> << than people who never used drugs. The risk was almost doubled for those who had more than 10 prescriptions over
those who had one to nine, according to research published today
in the British Medical Journal (BMJ) in Internet. There were no connection between drugs and stomach or bowel cancer. About three million people suffer from osteoporosis, according to the National Society >> osteoporosis. Duchess of Cornwall <<, whose mother and grandmother
both died of the disease, is president of the charitable organization. More than a million people have been appointed bisphosphonates in 2009/10
under the MHRA, working to prevent bone loss and restoration
lost bone. More than 6. 5000000 prescriptions were issued. They are a group of drugs that include alendronate, and etidronat ryzedronat. Doctors often prescribe them as a preventive measure for those who may be
a higher risk of osteoporosis, such as postmenopausal women. However, with
scarce believe that their side effects are known, include difficulties
swallowing, chest pain and heartburn. Dr. de Spence, Glasgow GP who also wrote on this subject in BMJ,
said doctors should pay less attention to drugs and more about how to avoid falling,
, and to improve nutrition and increase targeted measures. Dr. Spence described the research as "very significant". While he spoke oral bisphosphonates are widely used to prevent fractures
people who may be at risk of osteoporosis, he thought that approach "is not supported by evidence
". He was convinced the benefits outweigh the risks, he added. If the cancer link was correct, he said, "it would be >> << opportunity to reflect and think about using this drug, especially in the
people who havenot a history of fracture."
Dr. Jane Green, lead author of the study, said that the results were "part
bigger picture" because bisphosphonates were "more >> << prescribed to prevent fractures." She said, "that the lack of reliable information about benefits and risks
use them in the long run."
However, she added. " Cancer of esophagus is rare increased risk we
was found in people who have used oral bisphosphonates for five years, and
even if our results are confirmed, some people taking bisphosphonates are
likely to develop esophageal cancer as a result of taking these drugs. "
Their research contradicts the one published a few weeks ago, using the same
dataset that showed no link between drugs and diseases. However, recent studies of patients should be almost twice as long and
had a great statistical power. MHRA spokesman said: "Based on the results of this survey >> << no need for patients to stop taking their bisphosphonates
medicine." However, in order to reduce the risk of irritation of the esophagus, which is
recognized risk associated with bisphosphonates is important to use
carefully follow the instructions in the patient information sheet. "Patients also should report any signs of irritation of the esophagus, such as
difficulty or pain upon swallowing, chest pain, heartburn or a doctor."
He added: "The safety of bisphosphonates and still be close.
Monitor "
Dr Laura Bell, Research Associate for Information on Cancer Research UK, said:" This >> << This important study that will help doctors better understand the risks> > << and benefits of oral bisphosphonates, but it is important to emphasize that even if buy generic lasix people
taking oral bisphosphonates for a long time the risk of esophageal cancer
, young. "Anyone who takes these drugs, and worry about their risk of cancer >> << should consult your doctor. "
A spokesman for the National Osteoporosis Society said:" When you
consider the fact that there are 230,000 fractures each year in the UK
and 1150 hip-fracture-related deaths each month, case for treatment >> << strong. "In addition, the researchers note that the risk is small, and
few people who take bisphosphonates may develop esophageal cancer."
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